You have all heard about the lost colony, right? England sent a bunch of colonists to Roanoke Island in Virginia, and all the colonists vanished, leaving only "CRO" and "CROATOAN" carved into a tree and a post, respectively.
It's possible you haven't. But that basically sums it up.
You will also find a fun summary in the first half of the outdoor symphonic drama The Lost Colony. This show is only performed in Manteo, North Carolina, at the Waterside Theatre. It comes highly recommended by locals this year, as well.
If you attend the show, you will experience live gunfire, a made-up Native American language that I'm told has no relation to any sort of Algonquian, Ananias Dare the obnoxious weenie (as my mother describes him), mosquitoes, a prerecorded introduction by Andy Griffith himself, and half-naked Native Americans.
It's an all around good time. Tickets are reasonably priced, and you'll be supporting the arts! Also, you'll find out why I called Eleanor Dare a sucker.
Potatoes and tobacco,